Ecdysterone is an all-natural supplement that has been shown to improve athletic performance and increase muscle mass. This supplement is derived from plant sources and is thought to help athletes increase their strength and endurance while reducing fatigue. Ecdysterone has been found to increase protein synthesis and reduce muscle breakdown, allowing athletes to train harder and longer, improving their performance. Additionally, this supplement may help improve overall health as it contains anti-inflammatory properties, aiding in injury prevention. With ecdysterone, athletes can unlock their athletic potential by increasing their performance and overall health.
What is Ecdysterone:
Depending on where you purchase the supplement, it might be known as:
• Spinach extract
Technically speaking, it's a type of phytoecdysteroid. However, it's important to note that "steroids," in this case, aren'taren't the same as synthetic anabolic steroids.
Recent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. However, scientific studies on humans are very rarely accessible. Thus, our project investigated the effects of ecdysterone-containing products on human sport exercise. A 10-week intervention study of strength training of young men (n = 46) was carried out. Different doses of ecdysterone-containing supplements have been administered during the study to evaluate the performance-enhancing effect. In addition, an analysis of blood and urine samples for ecdysterone and potential biomarkers of performance enhancement has been conducted. In addition, comprehensive screening for prohibited performance-enhancing substances was also carried out.
Furthermore, the administered supplement has been tested for the absence of anabolic steroid contaminations before administration. Significantly higher increases in muscle mass were observed in those participants that were dosed with ecdysterone. Even more relevant concerning sports performance, substantially more pronounced gains in one-repetition bench press performance were observed. No increase in biomarkers for liver or kidney toxicity was noticed. These data underline the effectiveness of ecdysterone supplementation concerning sports performance. Our results strongly suggest the inclusion of ecdysterone in the list of prohibited substances and methods in sports in class S1.2, " other anabolic agents."
Ecdysteroids are widely marketed to athletes as a dietary supplement, advertising to increase strength and muscle mass during resistance training, reduce fatigue, and ease recovery. The levels of ecdysteroids in the western diet are generally low (usually in the range of less than 1 mg · day−1), while the doses used by bodybuilders are stated in a range of up to 1000 mg · day.
Extensive investigations on the possible growth-promoting effects of ecdysterone in various animal species (rats, mice, Japanese quail, and cattle) and humans [1–13] were reported, and lots of rumors about its misuse by athletes have been circulating since then. Ecdysterone has increased protein synthesis in skeletal muscle . Gorelick et al. proposed direct or indirect stimulation of the PI3K/Akt signaling pathway as a mechanism for this increased protein synthesis [9, 15].
Conversely to anabolic-androgenic steroids (AAS) that increase muscle mass mainly through their binding to the androgen receptor (AR), no nuclear receptor that is homologous to the ecdysone atomic receptor found in insects has yet been described in mammals so far . Only recently, the binding of ecdysterone to the human ERβ (ED50 = 13 nM) could be shown in cell culture experiments, and induction of hypertrophy in C2C12 cells was shown to be mediated by the ERβ activation . This study aimed to elucidate the anabolic potency of ecdysterone compared to other known anabolic agents and to support the hypothesis of ERβ mediated action by in-silico modeling.
Male Wistar rats (n = 42, Janvier, Le-Genest St-Isle, France) were randomly allocated to verum and control groups. The animals were kept under controlled conditions (T = 20 ± 1°C, relative humidity Φ = 50–80%, 12-h light/12-h dark) with free access to a standard diet (SSniff GmbH, Soest, Germany) and water. Intact (i.e., non-castrated) animals were treated with 5 mg · kg−1 body weight of the respective substance once daily for 21 days. The control groups were injected with vehicles only. The animals were handled in compliance with accepted veterinary medical practice and with the approval of the Animal Welfare Committee. Further experimental details were performed as described earlier.
The anabolic potency of ecdysterone was determined using the muscle fiber size of the soleus muscle of male Wistar rats as a measure.
To mimic the situation in athletes, intact male Wistar rats were treated with the test components for 21 days. Significantly increased fiber sizes of the soleus muscle were determined following treatment with ecdysterone.
In addition, a water molecule mediating meaningful interaction in the testosterone complex is replaced by a methyl group for the ecdysterone docking pose resulting in an unfavorable interaction pattern.
Our investigation confirmed the anabolic activity of ecdysterone. Moreover, in-silico docking experiments support the postulated non-androgenic mechanism of ecdysterone. More likely and in agreement with the experimental data, the anabolic activity of ecdysterone is mediated via binding to the ER, particularly ER beta. Concerning doping prevention, the high anabolic potency of ecdysterone justifies its classification as an anabolic agent. It, therefore, needs to be listed in the category "S1 Anabolic Agents" on the list of prohibited substances of the World Anti-Doping Agency.
The Benefits of Taking Ecdysterone
#1 Improved Muscle Gains.
#2 Boosts Strength and Athletic Performance.
#3 Improves Recovery.
#4 Improve Insulin Sensitivity.
#5 Supports Immune Function.
• Ecdysterone and creatine — Creatine is one of the most researched sports supplements on the market. ...
A few research papers show that the supplement has a high anabolic ratio, which means it can contribute to increased:
• protein synthesis from amino acids;
• bone remodeling and growth;
• muscle cell formation; and
• red blood cell production.
Its anabolic effects are mediated by its ER or estrogen receptor binding characteristics. ER signaling aids skeletal muscle growth and regeneration while improving immune function for added health and wellness.
A study performed in 2015 on rats uncovered that the supplement has a potent hypertrophic effect on some of the rats'rats' muscles. The outcome proves the impact was more substantial than steroid compounds, such as estradienedione, methandienone, and SARM-S-1 when taken at the exact dosage.
Boosts Strength and Athletic Performance
Ecdysterone supplements arena isn't just appealing for aesthetic reasons; they also increase strength by reducing muscular fatigue. The effects are so strong that it was nicknamed " the Russian secret" since Russian athletes purportedly used it during the Olympics.
Those who took the supplement showed a significant increase in their one-rep bench press maximum without suffering adverse effects, such as increased muscle damage or prolonged recovery.
A study conducted on rats also showed a huge boost in grip strength.
At the time, researchers found it so effective that they suggested adding it to the list of prohibited compounds for competitive athletes. Although it is not a synthetic anabolic steroid — keep your natty card in your wallet, people.
Muscle protein synthesis is a process that occurs naturally in your body to repair muscle damage caused by intense resistance or cardiovascular exercise.
But how does it do that?
In short, amino acids bind to skeletal muscle proteins, repairing damage and increasing muscle size. Effectively, it counteracts muscle protein breakdown or MPB due to training-induced protein loss.
Improve Insulin Sensitivity
Granted, more research on this specific benefit is needed. However, one animal study discovered that ecdysterone supplementation could support metabolic health by preventing insulin resistance.
The test, performed in 2009, showed that daily administration of ecdysterone in rats of 10mg per kilogram of body weight decreased obesity and insulin resistance in 13 weeks.
The rats ate a high-fat diet during the study, but the supplement prevented significant weight gain or fat mass increase compared with the control group. Those on ecdysterone also had considerably lowered plasma insulin levels and glucose tolerance.
Supports Immune Function
The compound supports healthy homeostasis and immune function in several ways, including:
• Increasing your red blood cell count
• Stimulating bone regeneration
• Boosting circulation and cardiac function
• Improving sleep quality
• Providing antioxidant and anti-inflammatory effects
• Improving thermal-related stress tolerance
Can athletes take ecdysterone?
The 10-week study of 46 male athletes revealed that athletes dosed with ecdysterone showed increased muscle mass and bench-pressed strength compared with athletes receiving a placebo.
Does ecdysterone increase muscle mass?
Other studies have demonstrated that ecdysterone "increases protein synthesis in skeletal muscle." As Prof. Parr explains, previous tests in vitro and in vivo showed that ecdysterone is more potent than other steroids banned in sports, such as methandienone.
Is ecdysteroids a steroid?
Ecdysteroids (zooecdysteroids) are steroid hormones that control the molting and reproduction of arthropods.
Does ecdysterone affect the kidney?
Ecdysteroid-containing adaptogens have been popularly used to improve well-being and by bodybuilders for muscle growth. However, using ecdysone in mammals is also associated with kidney growth and enlargement, indicating disturbed kidneys.
Is ecdysterone liver toxic?
In human subjects resulted in no elevation in biomarkers that would indicate liver or kidney toxicity.
From ecdysterone supplementation, we are providing evidence that ecdysterone is effective and SAFE!
Is ecdysterone proven to work?
Limited research suggests that supplements containing ecdysterone may enhance the effects of exercise on muscle mass.
Does ecdysterone increase testosterone levels? No. In one study on resistance-trained men, taking 200 mg of ecdysterone per day and following a well-designed 8-week strength training program did not affect active or free testosterone levels.
Is Beta Ecdysterone good for you?
According to some studies, including one recent one conducted at Freie Universität in Germany, the compound called ecdysterone may be an incredibly effective supplement for enhancing strength and muscle recovery.